Chronic Fatigue Syndrome
Chronic fatigue syndrome (CFS), fibromyalgia and multiple chemical sensitivities (MCS) constitute three different clinical entities that are, however, associated (Jason et al., 2000; White et al., 2000) and that in the past were grouped under the term neurasthenia (Schäfer, 2002).
It was not until the mid-1980s that CFS was recognized as a separate disease. At the […]
Proctocolitis and Crohn’s Disease
Ulcerative colitis and Crohn’s disease are two types of inflammatory disease in adults with different etiologies. Their common denominator is a genetic predisposition for exaggerated responses by the intestinal immune system.
A deficiency in or reduced activity of suppressive cytokines, particularly TGF-b, may play an important role in the pathogenesis of these inflammatory diseases (Kanazawa et […]
Celiac disease
Celiac disease is probably the prototype of pathologies linked to hypersensitivity to cereals, which to date have not yet been elucidated. It is similarly supposed that in many patients some systemic diseases are due to regular ingestion of cereals.
During the past decade, evolution of scientific knowledge has revealed new concepts in pathophysiology and in the […]
Atopic Dermatitis
Atopic dermatitis is a chronic inflammatory disease of the skin with a genetic predisposition, of unknown origin, the prevalence of which is growing in industrialized countries.
Although in most cases the symptomatology is relatively moderate, atopic dermatitis can be severe and extensive, significantly affecting the quality of patients’ lives (Oranje and de Waard-van der Spek, 2002). […]
Type 2 Diabetes
Non-insulin-dependent diabetes and obesity are two metabolic disorders that are closely related because insulin resistance constitutes a common complication of excess weight and is the key element of non-insulin-dependent diabetes. A disrupted inflammatory response plays an essential role in insulin resistance (Grimble, 2002).
The inflammatory response constitutes an essential defence mechanism against pathogens. TNFa, IL-1 and […]
Rheumatoid Arthritis
Rheumatoid arthritis (RA) is often considered an auto-immune disease with a strong inflammatory response. TNF-a plays a major role in the pathogenesis of rheumatoid arthritis (Moreland, 2001). Dietary etiology and the issue of whether diet can favourably influence the regression of the disease remain topics of public and scientific discourse. Foods most often implicated include […]
Obesity
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Type 1 Diabetes
Insulin-dependent diabetes is an auto-immune disease resulting in the progressive destruction of insulin-producing beta cells in the pancreas.
The pathogenesis entails a genetic predisposition and environmental factors. Many genes confer susceptibility to Type I diabetes and most of them are involved in the immune response. These include local determinants of the major histocompatibility complex (MHC) designated […]
